Multicenter randomized trial performed in the UK Major Trauma Network in order to evaluate the disability, rate of deep infection, and quality of life in subjects with severe open fracture of the lower limb treated with negative pressure wound therapy (NPWT) vs standard wound management after the first surgical debridement of the wound. Researchers reported that use of NPWT compared with standard wound dressing did not improve self-rated disability at 12 months among subjects with a severe open fracture of the lower limb. This treatment was not recommended for severe open fractures.

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