Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute have developed a new bone engineering technique called Segmental Additive Tissue Engineering (SATE). The technique, described in a paper published online today in Scientific Reports, allows researchers to combine segments of bone engineered from stem cells to create large scale, personalized grafts that will enhance treatment for those suffering from bone disease or injury through regenerative medicine.
“We are hopeful that SATE will one day be able to improve the lives of the millions of people suffering from bone injury due to trauma, cancer, osteoporosis, osteonecrosis, and other devastating conditions,” says Susan L. Solomon, NYSCF CEO. “Our goal is to help these patients return to normal life, and by leveraging the power of regenerative medicine, SATE brings us one step closer to reaching that goal.”
Over a million individuals per year will suffer from a fracture due to bone disease, and as people age, their bones get weaker, leading to complications later in life. From traumatic injuries due to car accidents, domestic violence, and service in combat to genetic malformation resulting from diseases like osteogenesis imperfecta, the burden of bone deficiencies is massive and rapidly increasing.
“Bone defects obtained in disease or injury are a growing issue, and having effective treatment options in place for personalized relief, no matter the severity of a patient’s condition, is of critical importance,” explains NYSCF – Ralph Lauren Senior Principal Investigator Giuseppe de Peppo, PhD, who led the study.
Bone defects are currently treated with either synthetic substitutes or bone grafts taken from a bone bank or another part of the patient’s body. However, these treatments often spark immune rejection, do not form connective tissue or vasculature needed for functional bone, and can be quickly outgrown by pediatric patients. Bone grafts generated from patient stem cells overcome such limitations, but it is difficult to bioengineer these grafts in the exact size and shape needed to treat large defects.