The efficacy and safety of tranexamic acid (TXA) usage in femoral fracture surgery was assessed by analyzing data from relevant studies identified via search through four electronic databases, with end points being total blood loss, postoperative hemoglobin decline, transfusion rate, thromboembolic events, 90-day mortality, and operative time. Researchers used Stata 14.0 software and the present study was performed following Cochrane Reviewers’ Handbook and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. They analyzed 12 randomized controlled trials (RCTs) and one retrospective cohort study; 11 studies concerning intravenous (IV) application of TXA and three studies concerning topical administration of TXA. They found that reduced transfusion rate in femoral fracture surgery was achieved with both IV and topical application of TXA.

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